The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete...

The authors illustrate how to perform maximum-likelihood estimation in latent class (LC) analysis when there are sampling weights. The methods are natural extensions of the approaches proposed by Clogg and Eliason (1987) and Magidson (1987) for dealing with sampling weights in the log-linear...

State space models provide a useful stochastic description for dynamic phenomena, based on unobserved or latent variables. When the model rests on linear and Gaussian assumptions there exists a well-known iterative procedure, called the Kalman filter, which gives analytic updating recursion for...

In this article, we present a statistical model for mapping quantitative trait loci (QTL) that determine growth trajectories of two correlated traits during ontogenetic development. This model is derived within the maximum likelihood context, incorporated by mathematical aspects of growth...