Search Results - subject:"Effect modification"

A fundamental measure of treatment effect heterogeneity

Levy, Jonathan; van der Laan, Mark; Hubbard, Alan; … - In: Journal of Causal Inference 9 (2021) 1, pp. 83-108

Abstract The stratum-specific treatment effect function is a random variable giving the average treatment effect (ATE) for a randomly drawn stratum of potential confounders a clinician may use to assign treatment. In addition to the ATE, the variance of the stratum-specific treatment effect...

Persistent link: https://www.econbiz.de/10014610883

Heterogeneous indirect effects for multiple mediators using interventional effect models

Loh, Wen Wei; Moerkerke, Beatrijs; Loeys, Tom; … - In: Epidemiologic Methods 9 (2021) 1

that encode the interventional indirect effects as causal model parameters, thus readily permitting effect modification by …

Persistent link: https://www.econbiz.de/10014590669

Is network meta-analysis as valid as standard pairwise meta-analysis? It all depends on the distribution of effect modifiers

Jansen, Jeroen P.; Naci, Huseyin - London School of Economics (LSE) - 2013

Background In the last decade, network meta-analysis of randomized controlled trials has been introduced as an extension of pairwise meta-analysis. The advantage of network meta-analysis over standard pairwise meta-analysis is that it facilitates indirect comparisons of multiple interventions...

Persistent link: https://www.econbiz.de/10011126556

A Tutorial on Interaction

VanderWeele, Tyler J.; Knol, Mirjam J. - In: Epidemiologic Methods 3 (2014) 1, pp. 33-72

Abstract In this tutorial, we provide a broad introduction to the topic of interaction between the effects of exposures. We discuss interaction on both additive and multiplicative scales using risks, and we discuss their relation to statistical models (e.g. linear, log-linear, and logistic...

Persistent link: https://www.econbiz.de/10014590592

Substance use, generation and time in the United States: The modifying role of gender for immigrant urban adolescents

Almeida, Joanna; Johnson, Renee M.; Matsumoto, Atsushi; … - In: Social Science & Medicine 75 (2012) 12, pp. 2069-2075

Although immigrant youth have lower rates of substance use than US born youth, whether substance use varies by generation and time in the US is unclear. This study examines adolescent alcohol, tobacco and marijuana use by generation/time in US (i.e., first generation, in US ≤4 years; first...

Persistent link: https://www.econbiz.de/10011042609

Confounding and Effect Modification: Distribution and Measure

VanderWeele, Tyler J. - In: Epidemiologic Methods 1 (2012) 1, pp. 55-82

Abstract The paper considers the properties of and relations between confounding and effect modification from the … of confounding depends on how the exposure was assigned; the presence of effect modification does not. The possibility of … confounding without effect modification and vice versa is discussed both with respect to distribution and measure. Discussion is …

Persistent link: https://www.econbiz.de/10014590578

Evaluating Markers for Selecting a Patient's Treatment

Song, Xiao; Pepe, Margaret - Berkeley Electronic Press - 2004

Selecting the best treatment for a patient's disease may be facilitated by evaluating clinical characteristics or biomarker measurements at diagnosis. We consider how to evaluate the potential of such measurements to impact on treatment selection algorithms. For example, magnetic resonance...

Persistent link: https://www.econbiz.de/10005751053