The Rock–Paper–Scissors (RPS) game is a widely used model system in game theory. Evolutionary game theory predicts the existence of persistent cycles in the evolutionary trajectories of the RPS game, but experimental evidence has remained to be rather weak. In this work, we performed...

The number of distinct functional classes of single-stranded RNAs (ssRNAs) and the number of sequences representing them are substantial and continue to increase. Organizing this data in an evolutionary context is essential, yet traditional comparative sequence analyses require that homologous...

Like proteins, single-stranded RNA's (ssRNAs) undergo intramolecular folding into complex conformations which determine their metabolic function. We have compiled nucleotide composition data, expressed as G+A and G+U in addition to G+C content, from phylogenetically representative samples of...