Search Results - subject:"Group-sequential"

Pre-registered interim analysis designs (PRIADs) : increasing the cost-effectiveness of hypothesis testing

André, Quentin; Reinholtz, Nicholas - In: Journal of consumer research : JCR ; an … 51 (2024) 4, pp. 845-865

Persistent link: https://www.econbiz.de/10015338618

Optimal dose de-escalation trial designs for novel contraceptives in women

Gerlinger, Christoph; Siedentop, Harald; Gerke, Oke; … - In: Computational Statistics & Data Analysis 56 (2012) 5, pp. 1061-1068

Dose finding for classical hormonal contraceptives for women is usually done by investigating the surrogate endpoint inhibition of ovulation. For novel compounds such an approach is not feasible because they do not necessarily inhibit ovulation and no other surrogate endpoint for pregnancy is...

Persistent link: https://www.econbiz.de/10011056544

Sequential methods for pharmacogenetic studies

Todd, Susan; Fazil Baksh, M.; Whitehead, John - In: Computational Statistics & Data Analysis 56 (2012) 5, pp. 1221-1231

A study or experiment can be described as sequential if its design includes one or more interim analyses at which it is possible to stop the study, having reached a definitive conclusion concerning the primary question of interest. The potential of the sequential study to terminate earlier than...

Persistent link: https://www.econbiz.de/10010574491

Exact sequential test of equivalence hypothesis based on bivariate non-central t-statistics

Liu, Fang; Li, Qing - In: Computational Statistics & Data Analysis 77 (2014) C, pp. 14-24

A critical step in group sequential designs is computation of the appropriate critical values for rejecting H0 at the …

Persistent link: https://www.econbiz.de/10010785334

Group sequential comparison of two binomial proportions under ranked set sampling design

Hussein, A.; Muttlak, H.; Saleh, M. - In: Computational Statistics 28 (2013) 3, pp. 1169-1194

testing procedures right at the design stage. In this paper, we propose group sequential testing procedures for comparing two … I errors of the proposed tests to those of the group sequential tests based on simple random sampling schemes. We …

Persistent link: https://www.econbiz.de/10010847963

Group sequential methods based on ranked set samples

Hussein, A.; Muttlak, H.; Al-Sawi, E. - In: Statistical Papers 54 (2013) 3, pp. 547-562

, group sequential methods provide substantial savings in sample and enable us to make decisions as early as possible. In this … manuscript, we intend to combine the benefits of the two methodologies. We propose group sequential tests for one and two … population means under RSS. We compare the power, average sample sizes and type I errors of the proposed tests to those of group …

Persistent link: https://www.econbiz.de/10010848040

Group sequential tests under fractional Brownian motion in monitoring clinical trials

Lai, Dejian - In: Statistical Methods and Applications 19 (2010) 2, pp. 277-286

Persistent link: https://www.econbiz.de/10008486565

Sequential Methods for Comparing Years of Life Saved in the Two-Sample Censored Data Problem

Murray, Susan; Tsiatis, Anastasios A. - 1999

This research develops nonparametric strategies for sequentially monitoring clinical trial data where detecting years of life saved is of interest. The recommended test statistic looks at integrated differences in survival estimates during the time frame of interest. In many practical...

Persistent link: https://www.econbiz.de/10009477553

A group sequential test for the inverse Gaussian mean

Bacanli, Sevil; Demirhan, Yaprak - In: Statistical Papers 49 (2008) 2, pp. 377-386

Persistent link: https://www.econbiz.de/10008486820

On group sequential tests based on robust location and scale estimators in the two-sample problem

Christmann, Andreas - 1998

The behaviour of group sequential tests in the two-sample problem is investigated if one replaces the classical non …

Persistent link: https://www.econbiz.de/10011335348