Owing to the recent progress in high-throughput experimental techniques, the datasets of large-scale protein interactions of prototypical multicellular species, the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster, have been assayed. The datasets are obtained mainly...

In this paper, we present a versatile method for the investigation of interaction networks and show how to use it to assess effects of indirect interactions and feedback loops. The method allows to evaluate the impact of optimization measures or failures on the system. Here, we will apply it to...