Nguyen, Thu Thuy; Mentré, France - In: Computational Statistics & Data Analysis 80 (2014) C, pp. 57-69
. Presently, MF in NLMEM is mostly evaluated with first-order linearisation. The adequacy of this approximation is, however …, influenced by model nonlinearity. Alternatives for the evaluation of MF without linearisation are proposed, based on Gaussian …. Their relevance was compared with clinical trial simulation and linearisation, using dose–response models, with various …