This article introduces the concept of network entropy as a characteristic measure of network topology. We provide computational and analytical support for the hypothesis that network entropy is a quantitative measure of robustness. We formulate an evolutionary model based on entropy as a...

We ask whether natural selection has shaped three biologically important features of 15 signal transduction networks and two genome-scale transcriptional regulation networks. These features are regulatory cycles, the lengths of the longest pathways through a network — a measure of network...