Newberg, Lee; McCue, Lee Ann; Lawrence, Charles - In: Statistical Applications in Genetics and Molecular Biology 4 (2007) 1, pp. 13-13
Approaches based upon sequence weights, to construct a position weight matrix of nucleotides from aligned inputs, are popular but little effort has been expended to measure their quality.We derive optimal sequence weights that minimize the sum of the variances of the estimators of base frequency...
