In many applications it is known that the underlying smooth function is constrained to have a specific form. In the present paper, we propose an estimation method based on the regression spline approach, which allows to include concavity or convexity constraints in an appealing way. Instead of...

The Northern Manhattan Study (NOMAS) is a prospective, population-based study. One of the goals of NOMAS is to characterize the functional status of stroke survivors over time after stroke. Based on generalized estimating equation models, previous parametric analysis showed that functional...