Abstract We develop a transport formula for predicting overall cumulative vaccine efficacy through time t ( $$VE(t)$$ ) to prevent clinically significant infection with a genetically diverse pathogen (e. g., HIV infection) in a new setting for which a Phase III preventive vaccine efficacy...

In clinical and epidemiological studies, matched case-control designs have been used extensively to investigate the relationships between disease/response and exposure/covariate. Due to the retrospective nature of the study, some covariates may not be observed for all study subjects and missing...

In this study, a more general single-index regression model was presented to characterize the relationship between a dichotomous response and covariates of interest. With M-phase (M≥2) case-control data supplemented by information on a response and certain covariates, we propose a pseudo...