Miller, Frank; Dette, Holger; Guilbaud, Olivier - Institut für Wirtschafts- und Sozialstatistik, … - 2007
We consider a dose-finding trial in phase IIB of drug development. For choosing an appropriate design for this trial … using optimal design theory. In particular we determine non-adaptive Bayesian optimal designs, i.e. designs which are not … changed by information obtained from an interim analysis. Compared with a traditional balanced design for this trial it is …