Recently, a Bayesian paradigm was constructed for Phase I trial designs that allows for theevaluation and comparison of several nested treatment schedules, each consisting of a sequence ofadministration times. In contrast to traditional Phase I trial designs that seek to find a maximum...

Value-at-Risk (VaR) determines the probability of a portfolio of assets losing a certain amount in a given time period due to adverse market conditions with a particular level of confidence. Value-at-Risk has received considerable attention from financial economists and financial practitioners...