. The new lead time TTO is compared to an equally viable method called lag time TTO, both in two time frames. We test … TTO specifications but with a different mode of administration. Lag time TTO produced lower values than lead time TTO and …

‘lead time’ TTO and ‘lag time’ TTO, have been developed to overcome methodological issues of the ‘classic’ TTO. In the lead … time TTO, ill-health is explicitly placed in the future, after a period of good health, while in lag time TTO a health … properties of lead and lag time TTO. In particular, we use data from a previous study that employed lead and lag time TTO to …