Siegmund, Kimberly; Marjoram, Paul; Shibata, Darryl - In: Statistical Applications in Genetics and Molecular Biology 7 (2008) 1, pp. 18-18
Little is known about how human cancers grow because direct observations are impractical. Cancers are clonal populations and the billions of cancer cells present in a visible tumor are progeny of a single transformed cell. Therefore, human cancers can be represented by somatic cell ancestral...