Luttmann, Reiner; Bitzer, Gerhard; Hartkopf, Jens - In: Mathematics and Computers in Simulation (MATCOM) 37 (1994) 2, pp. 153-164
The high cell density cultivation (HCDC) of genetically modified microorganisms, e.g. E. coli, with dry weight larger than 100 g⧸l, requires fed-batch processing with aid of a controlled specific growth rate μ. A general mathematical model of HCDC as well as different methods to control μ is...
