During the many years that I was a founding member of the MIT Industrial Dynamics (ID) Group, later System Dynamics (SD), I focused on trying to apply SD concepts, tools and techniques to the real world and to having real impact. That orientation originated from listening to Jay Forrester as he...

How does the relationship between founding team composition and venture performance depend on the venture’s strategy and business environment? Using data from a novel survey of 2,067 firms, we show that while diverse founding teams tend to exhibit higher performance, this is not universally...

Organizational design in the context of new venture development is particularly challenging due to initially severe resource constraints. We address the question of when initial venture idea assets versus founder contracting experience are more important for venture performance. One view of new...

Research- and technology-intensive universities, especially via their entrepreneurial spinoffs, have a dramatic impact on the economies of the United States and its fifty states. A new report on just one such university, the Massachusetts Institute of Technology, indicates conservatively that,...

Although the economic and welfare consequences of privatization processes have been widely studied, less attention has been paid to understanding how these processes affect corporate research and development (R&D), and hence the innovative performance of the firm. We propose to address these...

We initiated a randomized, placebo-controlled, phase 1/2 trial to evaluate the safety and immunogenicity of the S-268019-b recombinant protein vaccine, scheduled as 2 intramuscular injections given 21 days apart, in 60 randomized healthy Japanese adults. We evaluated 2 regimens of the S 910823...

In our first paper we proposed a dynamic theory relating alliances and acquisitions to the evolution of a technology and the market it serves. Industry structure and critical success factors change as the underlying technology evolves from phase to phase, competitive pressures exerted on a firm...

We discuss the characteristics of academic "spin-off processes" in environments outside of high tech clusters and where technology transfer and entrepreneurship infrastructures have been weak. To identify their implications for venture formation, we studied the case of Belgium, gathering data...

In this report, we assess the economic impact of MIT alumni-founded companies between 1950 and 2014. We estimate that MIT alumni have launched more than 30,000 active companies that employ roughly 4.6 million people and generate $1.9 trillion in annual revenues, which is approximately the size...

This paper analyzes major patterns and trends in entrepreneurship among technology-based university alumni since the 1930s by asking two related research questions: (1) Who enters entrepreneurship, and has this changed over time?; and (2) How does the rate of entrepreneurship vary with changes...