A study or experiment can be described as sequential if its design includes one or more interim analyses at which it is possible to stop the study, having reached a definitive conclusion concerning the primary question of interest. The potential of the sequential study to terminate earlier than...

Adaptive seamless phase II/III clinical trial designs allowing treatment selection at an interim analysis have gained much attention because of their potential benefits compared to more conventional drug development programmes with separate trials for individual phases. A scenario of particular...

A receiver operating characteristic (ROC) curve is a plot of two survival functions, derived separately from the diseased and healthy samples. A special feature is that the ROC curve is invariant to any monotone transformation of the measurement scale. We propose and analyse semiparametric and...

We develop semiparametric and parametric transformation models for estimation and comparison of ROC curves derived from measurements from two diagnostic tests on the same subjects. We assume the existence of transformed measurement scales, one for each test, on which the paired measurements have...

Consider a random sample from a statistical model with an unknown, and possibly infinite-dimensional, parameter - e.g., a nonparametric or semiparametric model - and a real-valued functional T of this parameter which is to be estimated. The objective is to develop bounds on the (negative)...

We consider a semiparametric and a parametric transformation-to-normality model for bivariate data. After an unstructured or structured monotone transformation of the measurement scales, the measurements are assumed to have a bivariate normal distribution with correlation coefficient „ , here...

This paper considers the problem of estimation when one of a number of populations, assumed normal with known common variance, is selected on the basis of it having the largest observed mean. Conditional on selection of the population, the observed mean is a biased estimate of the true mean....

Everyone here tonight must be aware by now that we have entered a new, technological era—in fact, a second industrial revolution. If you are not aware of the new developments taking place you are either blind, deaf—or, even worse,—either not interested or of the opinion that it does not...

This paper estimates the value of king mackerel bag limit changes with both stated and revealed preference methods. The 1997 Marine Recreational Fishery Statistical Survey allows estimation of the value of avoiding bag limit reductions with the random utility model and the contingent valuation...