The purpose of this paper is to extend the widely used classical Brownian motion technique for monitoring clinical trial data to a larger class of stochastic processes, i.e. fractional Brownian motion, and compare these results. The beta-blocker heart attack trial is presented as an example to...

In measuring the association between magnetic resonance spectroscopic imaging (MRSI)-observed neurochemicals from multiple sclerosis (MS) patients, the classic correlation coefficients such as the Pearson's r, Spearman's A and Kendall's F do not take into account the spatial dependence of the...

In this article, we extended the widely used Bland-Altman graphical technique of comparing two measurements in clinical studies to include an analytical approach using a linear mixed model. The proposed statistical inferences can be conducted easily by commercially available statistical software...

In this article, we used the data from the last three population censuses of China in 1982, 1990 and 2000, to study the dynamics of the sex ratio at birth and the infant mortality rate in China. In the late 1970s, China started its economic reform and implemented many family planning programs....