We construct locally E-optimal designs for the two parameter Michaelis-Menten model under various assumptions on the error structure. Illustrative examples are given and the performance of these designs are compared with D-optimal designs.

We consider a class of optimality criteria and show that each criterion has its unique and equivalent dual within the class. This property can be used to find a variety of optimal designs, including a class of compound optimal designs and their relationships. As an example, we show that one type...

The problem of determining optimal designs for least squares estimation is considered in the common linear regression model with correlated observations. The approach is based on the determination of ‘nearly’ universally optimal designs, even in the case where the universally optimal design...

A class of multiplicative algorithms for computing D-optimal designs for regression models on a finite design space is discussed and a monotonicity result for a sequence of determinants obtained by the iterations is proved. As a consequence the convergence of the sequence of designs to the...