Current technologies generate a huge number of single nucleotide polymorphism (SNP) genotype measurements in case-control studies. The resulting multiple testing problem can be ameliorated by considering candidate gene regions. The <Emphasis Type="Bold">minPtest R package provides the first widely accessible...</emphasis>

Modern techniques for fitting generalized additive models mostly rely on basis expansions of covariates using a large number of basis functions and penalized estimation of parameters. For example, a mixed model approach is used to fit a model for children's lung function that allows for...

The bootstrap is a tool that allows for efficient evaluation of prediction performance of statistical techniques without having to set aside data for validation. This is especially important for high-dimensional data, e.g., arising from microarrays, because there the number of observations is...

Purpose One of the currently debated changes in scientific practice is the implementation of data sharing requirements for peer-reviewed publication to increase transparency and intersubjective verifiability of results. However, it seems that data sharing is a not fully adopted behavior among...

Summary For panels which are observed over a long time it has to be assumed that the effects of covariates vary across time. An estimation method based on local likelihood principles is proposed which allows to estimate the variation of coefficients in the case of discrete responses. Approximate...