Case-control association studies using unrelated cases and controls may suffer from potential confounding due to population stratification. Bias and variance distortion caused by population stratification in the commonly used allele-based tests can considerably inflate the Type I error rate. It...

Hidden population stratification (PS) is a main concern in the analysis of case-control genetic association studies. All methods to correct for hidden PS have been focused on classical hypothesis testing, and cannot be directly applied to Bayesian analysis. In this paper, to study the impact and...

After expressing the Fisher information in randomly censored data in terms of hazard rates, we examine the loss of Fisher information under the Koziol-Green random censoring model. Because the same parameter enters both the survival and censoring distributions in this model, the censored data...

We study the uniformity of two-level U-type designs based on the centered and wrap-around L2-discrepancies. Based on the known formulation of the measures of uniformity, we present some new lower bounds to centered and wrap-around L2-discrepancies, which can be used as benchmarks in searching...

Consider the interval mapping method for quantitative trait loci (QTL) detection of an experimental organism in a backcross population. In a recent paper, Chen and Chen [2005. On some statistical aspects of the interval mapping for QTL detection. Statist. Sinica 15, 909-925] show that the...