Tundra and taiga ecosystems comprise nearly 40 % of the terrestrial landscapes of Canada. These permafrost ecosystems have supported humans for more than 4500 years, and are currently home to ca. 115,000 people, the majority of whom are First Nations, Inuit and Métis. The responses of these...

The problem of relating genotype (as represented by amino acid sequence) to phenotypes is distinguished from standard regression problems by the nature of sequence data. Here we investigate an instance of such a problem where the phenotype of interest is HIV-1 replication capacity and contiguous...

This note is the authors' response to the Reader's Reaction provided by Foulkes and De Gruttola as published in Statistical Applications in Genetics and Molecular Biology

Since the demise of the Bretton Woods System of quasi‐fixed exchange rates in the early seventies, unanticipated exchange rate movements are a fundamental feature of the international economic environment. The ever increasing degree of exchange rates volatility has spurred the creation of new...

We identify operating exposure as the most important and difficult to manage component of exchange risk. Our model identifies three components of foreign exchange exposure: direct operating exposure, the market demand effect, and the competitive effect. The size and relative importance of these...