Background: Levels of measles in England and Wales are at their highest for 18 years and strategies targeting the different groups of parents who don’t vaccinate their children continue to be needed. Decision aids for childhood immunisation decisions appear to be effective in achieving vaccine...

Background: Diagnostic tests are often evaluated according to how the results will change clinical management. Patients may value information even if the management does not change. Objective: To investigate the willingness of adults with inherited retinal disease to undergo and pay for...

The challenge of implementing high cost innovative technologies in health care systems operating under significant budgetary pressure has seen a radical shift in the health technology reimbursement landscape. New reimbursement strategies attempt to reduce the risk of making the wrong decision;...

The arrival of personalized medicine in the clinic means that treatment decisions will increasingly rely on test results. The challenge of limited health care resources means that the dissemination of these technologies will be dependent on their value in relation to their cost; i.e. their cost...

Health care systems are increasingly under pressure to provide funding for innovative technologies. These technologies tend to be characterized by their potential to make valued contributions to patient health in areas of relative unmet need, high acquisition costs and great uncertainty in the...

Background: Trastuzumab has significantly improved survival outcomes for women with HER2 positive early breast cancer. Trastuzumab was established as a costeffective adjuvant treatment in 2006. We present an updated cost-effectiveness analysis from the UK perspective which explores assumptions...

Cystic fibrosis (CF) is an autosomal recessive genetic disorder; it is most common in the Caucasian populations, with a prevalence of about 1 per 2500 births. The disorder is associated with progressive lung disease and pancreatic enzyme deficiency, leading to considerable morbidity and...