Most findings from genome-wide association studies (GWAS) are consistent with a simple disease model at a singel nucleotide polymorphism, in which each additional copy of the risk allele increases risk by the same multiplicative factor, in contrast to dominance or interaction effects. As others...

Vote-tabulation audits can be used to collect evidence that the set of winners of an election (the outcome) according to the machine count is correct — that it agrees with the outcome that a full hand count of the audit trail would show. The strength of evidence is measured by the p-value of...

Epidemiologic methods were developed to prove general causation: identifying exposures that increase the risk of particular diseases. Courts often are more interested in specific causation: On balance of probabilities, was the plaintiff's disease caused by exposure to the agent in question? Some...

Many studies draw inferences about multiple endpoints but ignore the statistical implications of multiplicity. Effects inferred to be positive when there is no adjustment for multiplicity can lose their statistical significance when multiplicity is taken into account, perhaps explaining why such...

Consider the problem of constructing a fixed-length confidence interval for [theta]0 from the observation Y ~ N([theta]0, [sigma]2), when we know a priori that [theta]0 [epsilon][-[tau], [tau]]. The length of the minimax confidence interval centered at an affine functional of Y can be computed...