operating characteristic (ROC) curve, when the joint normality of biomarkers is assumed. However, in many investigations, the … emphases are placed only on a limited extent of clinical relevancy, instead of the whole ROC curve. The goal of this study is … to find the linear combination that maximizes the partial area under a ROC curve (pAUC) for a pre-specified range. In …

sensitivity, equivalent to a smaller false discovery rate, if the signal-discovering protocol implemented within the computed … focal regions is different from that used outside of the focal regions. We also numerically compute the specificity as the …