The penalized spline method has been widely used for estimating univariate smooth functions based on noisy data. This paper studies its extension to the two-dimensional case. To accommodate the need of handling data distributed on irregular regions, we consider bivariate splines defined on...

We aim at modeling the survival time of intensive care patients suffering from severe sepsis. The nature of the problem requires a flexible model that allows to extend the classical Cox-model via the inclusion of time-varying and nonparametric effects. These structured survival models are very...