The purpose of this paper is to extend the widely used classical Brownian motion technique for monitoring clinical trial data to a larger class of stochastic processes, i.e. fractional Brownian motion, and compare these results. The beta-blocker heart attack trial is presented as an example to...

In measuring the association between magnetic resonance spectroscopic imaging (MRSI)-observed neurochemicals from multiple sclerosis (MS) patients, the classic correlation coefficients such as the Pearson's r, Spearman's A and Kendall's F do not take into account the spatial dependence of the...

In this article, we extended the widely used Bland-Altman graphical technique of comparing two measurements in clinical studies to include an analytical approach using a linear mixed model. The proposed statistical inferences can be conducted easily by commercially available statistical software...