Accurate diagnosis of a molecularly defined subtype of cancer is often an important step toward its effective control and treatment. For the diagnosis of some subtypes of a cancer, a gold standard with perfect sensitivity and specificity may be unavailable. In those scenarios, tumor subtype...

While the up-down method for estimating a percentage point on a dose-response curve has received considerable attention, a general Bayesian solution to the up-down design and estimation has never been presented, probably due to its computational complexity both in design and use. This paper...