Four-level response surface designs based on regular two-level fractional factorial designs were introduced by Edmondson (1991). Here, the methods are extended to include designs based on irregular two-level fractional factorials. These designs allow orthogonal blocking and require fewer...

Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical...