The study of HIV dynamics is one of the most important developments in recent AIDS research. It has led to a new understanding of the pathogenesis of HIV infection. Although important findings in HIV dynamics have been published in prestigious scientific journals, the statistical methods for...

Modelling of HIV dynamics in AIDS research has greatly improved our understanding of the pathogenesis of HIV-1 infection and guided for the treatment of AIDS patients and evaluation of antiretroviral therapies. Some of the model parameters may have practical meanings with prior knowledge...

Interval estimation of the x th effective dose (ED x ), where x is a prespecified percentage, has been the focus of interest of a number of recent studies, the majority of which have considered the case in which a logistic dose-response curve is correctly assumed. In this paper, we focus our...

Muller & Schmitt (1990) have considered the question of how to choose the number of doses for estimating the median effective dose (ED50) when a probit dose-response curve is correctly assumed. However, they restricted their investigation to designs with doses symmetrical about the true ED50. In...

A virologic marker, the number of HIV RNA copies or viral load, is currently used to evaluate antiretroviral (ARV) therapies in AIDS clinical trials. This marker can be used to assess the antiviral potency of therapies, but may be easily affected by clinical factors such as drug exposures and...

In clinical practice, the profile of each subject's CD4 response from a longitudinal study may follow a 'broken stick' like trajectory, indicating multiple phases of increase and/or decline in response. Such multiple phases (changepoints) may be important indicators to help quantify treatment...

The two-parameter Birnbaum--Saunders distribution is widely applicable to model failure times of fatiguing materials. Its maximum-likelihood estimators (MLEs) are very sensitive to outliers and also have no closed-form expressions. This motivates us to develop some alternative estimators. In...