This document presents a general guide to the analysis and evaluation of data from studies involving repeated exposures of toxicity test species to pesticides and other chemicals; and outlines the kind of information which should be included in an independent assessment of toxicity studies.

This document focuses on the health and environmental hazards of mixtures. The ILO/UNCETDG joint committee has elaborated criteria for classification of Physico-Chemical Hazards which are applicable to substances or mixtures. The classification of mixtures for Physico-Chemical Hazards is not...

To keep (Q)SAR applications on a solid scientific foundation, an international effort to articulate principles for (Q)SAR technology and to develop a guidance document for use of (Q)SAR in regulatory applications. This document presents those principles and helpful guides for validating (Q)SAR...

This guidance document is part of the OECD effort to provide guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely related chemicals as a group, or category,...

This document is a report of the Workshop on a framework for the development and use of integrated approaches to testing and assessment which was held on 17-19 November 2014 in Crystal City VA, USA. This framework should provide guiding principles, and technical guidance on how results from...

The purpose of this guidance is to harmonise the way non-guideline in vitro methods are described and thereby facilitate an assessment of the relevance of test methods for biological activities and responses of interest, and an assessment of the quality of data produced, irrespective of whether...

This scoping document aims at bringing forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, to provide recommendations for their development/use, and also, to identify aspects/blocks of the thyroid signalling pathways that are not covered and would...

This document presents a harmonized method for characterising, for assessment purposes, a specific subcategory of UVCBs (Substances of Unknown or Variable composition, Complex reaction products or Biological materials): hydrocarbon solvent substances. The method presented in this document gives...

Several models, tools and methods have been published in the past 20 years to include bioavailability in risk assessment and several OECD member countries already have developed frameworks and published guidance documents for taking metal specificities into account in environmental risk...

In this document the importance of mechanistic consideration in quantitative structure-activity relationship ((Q)SAR) analysis, the critical role of mechanistic consideration in improving various (Q)SAR approaches and possible integrative approaches of combining chemoinformatics and...