Testing ACS patients for KIF6 carrier status may be a cost-effective strategy at commonly accepted thresholds. Treating all patients with A80 is more expensive than treating patients on the basis of KIF6 results, but the modest gain in QALYs is achieved at a cost/QALY that is generally...

<Emphasis Type="Bold">Background: Mathematical models are commonly used to predict future benefits of new therapies or interventions in the healthcare setting. The reliability of model results is greatly dependent on accuracy of model inputs but on occasion, data sources may not provide all the required inputs....</emphasis>

<Emphasis Type="Bold">Background: A recent study found fewer hospitalizations for congestive heart failure (CHF) patients receiving high-dose versus low-dose statin therapy. <Emphasis Type="Bold">Objective: To examine the cost effectiveness of high-dose versus low-dose statin therapy in CHF patients. <Emphasis Type="Bold">Methods: Two scenarios...</emphasis></emphasis></emphasis>

<Emphasis Type="Bold">Objective: The aim of this study was to examine how calibration uncertainty affects the overall uncertainty of a mathematical model and to evaluate potential drivers of calibration uncertainty. <Emphasis Type="Bold">Methods: A lifetime Markov model of the natural history of human papillomavirus (HPV) infection and...</emphasis></emphasis>