We discuss optimal design problems for a popular method of series estimation in regression problems. Commonly used design criteria are based on the generalized variance of the estimates of the coefficients in a truncated series expansion and do not take possible bias into account. We present a...

In the common polynomial regression of degree m we determine the design which maximizes the minimum of the D-efficiency in the model of degree m and the D-efficiencies in the models of degree m – j,…, m + k (j, k 0 given). The resulting designs allow an efficient estimation of the...

We consider a class of optimality criteria and show that each crite- rion has its unique and equivalent dual within the class. This property can be used to find a variety of optimal designs, including a class of compound optimal designs and their relationships. As an example, we show that one...

This paper investigates the use of Design of Experiments in observational studies in order to select informative observations and features for classification. D-optimal plans are searched for in existing data and based on these plans the variables most relevant for classification are determined....

The Monod model is a classical microbiological model much used in microbiology, for example to evaluate biodegradation processes. The model describes microbial growth kinetics in batch culture experiments using three parameters: the maximal specific growth rate, the saturation constant and the...

We show that binary designs for cross-over models obtained from orthogonal arrays are universally optimal under correlated errors.

For the problem of checking linearity in a heteroscedastic nonparametric regression model under a fixed design assumption we study maximin designs which maximize the minimum power of a nonparametric test over a broad class of alternatives from the assumed linear regression model. It is...

This paper generalizes Kushner's (1997) method for finding optimal repeated measurements designs to optimal designs under an interference model. The model we assume is for a onedimensional layout without guard plots and with different left and right neighbour effects. The resulting optimal...

We consider a dose-finding trial in phase IIB of drug development. For choosing an appropriate design for this trial the specification of two points is critical: an appropriate model for describing the dose-effect relationship and the specification of the aims of the trial (objectives), which...

We consider the problem of constructing optimal designs for model discrimination between competing regression models. Various new properties of optimal designs with respect to the popular T-optimality criterion are derived, which in many circumstances allow an explicit determination of T-optimal...