Age related macular degeneration (AMD) is the leading cause of blindness in the United Kingdom and the rest of the western world. It occurs in 15% to 30% of individuals over 75 years of age. About 15% of these patients develop a more aggressive wet form of the disease that causes severe loss of...

The objective was to develop an economic prioritisation model to assist those involved in (i) the selection and prioritisation of health technology assessment topics and (ii) commissioning of HTA projects. The model used decision analytic techniques to estimate the expected costs and benefits of...

Disease management is attracting considerable attention from the pharmaceutical industry, which sees this as a way of extending its activities beyond drug development to health care management and organisation. However, it is unclear whether disease management offers advantages to the NHS or...

Meta-analysis provides a family of statistical techniques for combining the results of similar studies. This paper examines the meta-analysis of clinical data in economic studies, and points to the issues and considerations that must be addressed when designing and conducting a meta-analysis of...

There is increasing professional and policy interest in the role of clinical guidelines for promoting effective and efficient health care. The NHS Health Technology Assessment Programme identified an urgent need, when such guidelines are produced, to develop a framework and methods for...

Rationale: Although the methods of economic evaluation are widely established, very few evaluations of public health interventions exist and existing reviews suggest that such evaluations raise additional methodological challenges. Objectives: To assess whether the economic evaluation of public...

This article provides an overview of research, originally funded by the Department of Health, about the internal management and use of resources in residential child care. It explores ways in which children's homes are managed and leadership is established and the relationship of these to their...