Clinical trials play a decisive role in the drug approval processes. By completing a p-curve analysis of a newly compiled data set that consists of thousands of clinical trials, we substantiate that the occurrence of p-hacking in clinical trials is not merely hypothetical. Medical and...

The aim of this study was to assess the case fatality rate (CFR) of COVID-19 by performing a metaanalysis according to the air temperature and to determine if the temperature modifies the pandemic duration to the peak day for CFR of the COVID-19. A novel coronavirus spread began in December 2019...

The aim of this study was to assess the case fatality rate (CFR) of COVID-19 by performing a metaanalysis according to the air temperature and to determine if the temperature modifies the pandemic duration to the peak day for CFR of the COVID-19. A novel coronavirus spread began in December 2019...

This paper analyzes the debate over the international dissemination of data exclusivity as a form of protection for clinical trial data. This is a critical demand for pharmaceutical companies seeking larger market shares and longer periods of monopoly in order to recover investments in research...

When data are missing at random, the missing-data mechanism can be ignored but this assumption is not always intuitive for general patterns of missing data. In part I, we consider maximum likelihood (ML) estimation for a non-ignorable mechanism which is called almost missing at random (AMAR). We...