In an emergency department (ED), the demand for service is not constant over time. This cannot be accounted for by means of waiting lists or appointment systems, so capacity decisions are the most important tool to influence patient waiting times. Additional complexities result from the...

This article uses a sequentialized experimental design to select simulation input combinations for global optimization, based on Kriging (also called Gaussian process or spatial correlation modeling); this Kriging is used to analyze the input/output data of the simulation model (computer code)....

This paper presents a novel heuristic for constrained optimization of random computer simulation models, in which one of the simulation outputs is selected as the objective to be minimized while the other outputs need to satisfy prespecified target values. Besides the simulation outputs, the...