A population that can be joined at a known sequence of discrete times is sampled cross-sectionally, and the sojourn times of individuals in the sample are observed. It is well known that cross-sectioning leads to length-bias, but less well known that it may result also in dependence among the...

We consider the classical problem of selecting the best of two treatments in clinical trials with binary response. The target is to find the design that maximizes the power of the relevant test. Many papers use a normal approximation to the power function and claim that Neyman allocation that...

Phase I clinical trials are conducted in order to find the maximum tolerated dose (MTD) of a given drug from a finite set of doses. For ethical reasons, these studies are usually sequential, treating patients or group of patients with the best available dose according to the current knowledge....

Statistical models in econometrics, biology, and most other areas, are not expected to be correct, and often are not very accurate. The choice of a model for the analysis of data depends on the purpose of the analysis, the relation between the data and the model, and also on the sample or data...

A problem of optimally allocating partially effective ammunition x to be used on randomly arriving enemies in order to maximize an aircraft's probability of surviving for time t, known as the Bomber Problem, was first posed by Klinger and Brown (1968). They conjectured a set of apparently...

A stationary renewal process based on iid random variables $X_i$ is observed at a given time. The excess time, that is, the residual time until the next renewal event, is of course smaller than the total current $X$ which consists of the residual time plus the current age. Nevertheless in...

In the context of survival analysis, we define a covariate X as protective (detrimental) for the failure time T if the conditional distribution of [T | X = x] is stochastically increasing (decreasing) as a function of x. In the presence of another covariate Y, there exist situations where [T | X...

We consider a permutation method for testing whether observations given in their natural pairing exhibit an unusual level of similarity in situations where any two observations may be similar at some unknown baseline level. Under a null hypothesis where there is no distinguished pairing of the...

An evolutionarily stable strategy (ESS) is an equilibrium strategy that is immune to invasions by rare alternative ("mutant") strategies. Unlike Nash equilibria, ESS do not always exist in finite games. In this paper, we address the question of what happens when the size of the game increases:...