The objective of this paper is to extend the surrogate endpoint validation methodology proposed by Buyse et al. (2000) to the case of a longitudinally measured surrogate marker when the endpoint of interest is time to some key clinical event. A joint model for longitudinal and event time data is...

Infectious bovine rhinotracheitis is caused by the bovine herpesvirus type 1. It is an enzootic disease on the B List of the Office International des Epizooties (O.I.E.). Programs to eradicate bovine herpesvirus type I have been implemented in several European countries to facilitate the free...

In a recent paper González Manteiga and Vilar Fernández (1995) considered the problem of testing linearity of a regression under MA(infinity) structure of the errors using a weighted L2-distance between a parametric and a nonparametric fit. They established asymptotic normality of the...