The contributions of Ernest Lhoste are largely unknown outside France, and even within that country are not well known. His important contributions were in the two areas of the development of prior distributions that represent little or no information, and a sophisticated posterior analysis for...

The randomized discontinuation trial (RDT) design is an enrichment-type design that has been used in a variety of diseases to evaluate the efficacy of new treatments. The RDT design seeks to select a more homogeneous group of patients, consisting of those who are more likely to show a treatment...