The joint effect of several variables is a prevailing statistical concept in biology. The public health importance of developing methods to better assess joint effects is evident when studying gene combinations that function together to produce a disease phenotype, or biomarker pairs that...

Many research areas require multiple outcomes. For example, neuropsychological hypotheses may not be testable using a single measure. Similarly, genetic researchers frequently examine multiple markers across the genome. Examining multiple hypotheses requires the use of multiple testing...