The English version of the WPAI-GERD showed good cross-sectional construct validity, and results indicated that the WPAI-GERD is responsive to change. Although the results also indicated that longitudinal construct validity may be poor, the overall findings suggest that further study of the...

Background: Peptic ulcer bleeding (PUB) is a serious and sometimes fatal condition. The outcome of PUB strongly depends on the risk of rebleeding. A recent multinational placebo-controlled clinical trial (ClinicalTrials.gov identifier: NCT00251979) showed that high-dose intravenous (IV)...

Objectives: To evaluate the cost effectiveness of on-demand treatment with esomeprazole 20mg compared with two alternative omeprazole treatment strategies for the long-term management of patients with gastro-oesophageal reflux disease (GORD) without oesophagitis. Design: A simple Markov model...

Background: Clinical studies have demonstrated that esomeprazole is superior to omeprazole for the acute treatment of reflux oesophagitis. Objective: To compare the cost effectiveness of esomeprazole 40mg once daily with omeprazole 20mg once daily in patients with reflux oesophagitis. Methods:...

Health impairment often leads to work impairment in the form of both absenteeism and presenteeism (i.e. reduced productivity while at work). Several self-report productivity instruments have been designed over the past few years to measure the impact of illness on productivity at work and/or in...

Model selection strategies play an important, if not explicit, role in quantitative research. The inferential properties of these strategies are largely unknown, therefore, there is little basis for recommending (or avoiding) any particular set of strategies. In this paper, we evaluate several...

Limited availability of irrigation water has placed pressure on farmers and water authorities to improve the efficiency of their operations. ‗Modernisation‘ of irrigation infrastructure systems is occurring throughout Australia in order to improve system delivery efficiency and...

SummaryNearly one tenth (8 per cent) of each cohort of school leavers in Northern Ireland experience long spells of unemployment and inactivity (“Status 0â€) between the ages of 16 and 18. This is important because many such young people are likely to end up unemployed and long-term...