Based on this review there is a dearth of up-to-date, robust evidence on the cost effectiveness of radiotherapy in cancer suitable to support decision making in the UK. Studies selected did not fully satisfy essential method standards currently recommended by NICE. </AbstractSection> Copyright The Author(s) 2014

We consider iterative trust region algorithms for the unconstrained minimization of an objective function <InlineEquation ID="IEq1"> <EquationSource Format="TEX">$F ( \underline{x})$</EquationSource> </InlineEquation>, <InlineEquation ID="IEq2"> <EquationSource Format="TEX">$\underline{x}\in \mathcal{R}^{n}$</EquationSource> </InlineEquation>, when F is differentiable but no derivatives are available, and when each model of F is a linear or a quadratic polynomial. The...</equationsource></inlineequation></equationsource></inlineequation>