We consider the common nonlinear regression model where the variance as well as the mean is a parametric function of the explanatory variables. The c-optimal design problem is investigated in the case when the parameters of both the mean and the variance function are of interest. A geometric...

The objective of this paper is to extend the surrogate endpoint validation methodology proposed by Buyse et al. (2000) to the case of a longitudinally measured surrogate marker when the endpoint of interest is time to some key clinical event. A joint model for longitudinal and event time data is...

Infectious bovine rhinotracheitis is caused by the bovine herpesvirus type 1. It is an enzootic disease on the B List of the Office International des Epizooties (O.I.E.). Programs to eradicate bovine herpesvirus type I have been implemented in several European countries to facilitate the free...