When comparing outcomes, such as survival, in two groups- say a focal group and a comparison group-a common question is whether an adjustment for certain baseline differences that separate these two groups actually matters for the difference in outcomes. Did the adjustment matter? If it did...

In a randomized trial, subjects are assigned to treatment or control by the flip of a fair coin. In many nonrandomized or observational studies, subjects find their way to treatment or control in two steps, either or both of which may lead to biased comparisons. By a vague process, perhaps...

An instrument or instrumental variable is often used in an effort to avoid selection bias in inference about the effects of treatments when treatment choice is based on thoughtful deliberation. Instruments are increasingly used in health outcomes research. An instrument is a haphazard push to...

Clustered treatment assignment occurs when individuals are grouped into clusters prior to treatment and whole clusters, not individuals, are assigned to treatment or control. In randomized trials, clustered assignments may be required because the treatment must be applied to all children in a...

In a case-referent study, cases of disease are compared to noncases with respect to their antecedent exposure to a treatment in an effort to determine whether exposure causes some cases of the disease. Because exposure is not randomly assigned in the population, as it would be if the population...