In the USA cancer as a whole is the second leading cause of death and a major burden to health care; thus medical progress against cancer is a major public health goal. There are many individual studies to suggest that cancer treatment breakthroughs and early diagnosis have significantly improved...

The method of Bayesian model selection for join point regression models is developed. Given a set of "K"+1 join point models "M"₀, "M"₁, …, "M"_{" K"} with 0, 1, …, "K" join points respec-tively, the posterior distributions of the parameters and competing models "M"_"k" are computed...

We review sequential designs, including group sequential and two-stage designs, for testing or estimating a single binary parameter. We use this simple case to introduce ideas common to many sequential designs, which in this case can be explained without explicitly using stochastic processes. We...