<Emphasis Type="Bold">Background: Migraine is a prevalent and incapacitating condition that affects individuals in the prime of their productive life, thus generating an economic burden for both society and healthcare systems. The direct annual healthcare costs of migraine in France were assessed over 10 years ago,...</emphasis>

Background: Migraine is a prevalent and incapacitating condition that affects individuals in the prime of their productive life, thus generating an economic burden for both society and healthcare systems. The direct annual healthcare costs of migraine in France were assessed over 10 years ago,...

In this paper we consider the problem of rebalancing an existing financial portfolio, where transaction costs have to be paid if we change the amount held of any asset. These transaction costs can be fixed (so paid irrespective of the amount traded provided a trade occurs) and/or variable...

The need to increase energy security and promote development, especially in rural areas has forced many developing countries in southern Africa, like Mozambique to take several actions toward development of several infrastructures and legislations for production and use of liquid biofuels. The...

This paper examines the application of genetic algorithm, tabu search and simulated annealing metaheuristic approaches to finding the cardinality constrained efficient frontier that arises in financial portfolio optimisation. We consider the mean-variance model of Markowitz as extended to...