Costs of screening a series of 18, 152 newborn males for Duchenne muscular dystrophy (DMD) in Canada were evaluated. The final aim of neonatal screening for DMD is the avoidance of additional cases in the families identified. Total costs to avoid one case of DMD were estimated at Cdn. $172,000,...

For a smoothing spline or general penalized spline model, the smoothing parameter can be estimated using residual maximum likelihood (REML) methods by expressing the spline in the form of a mixed model. The possibility of bimodality in the profile log-likelihood function for the smoothing...

This paper presents an application of the exact solution approach for the Vehicle Routing Problem with Soft Time Windows based on the column generation scheme developed earlier by the authors, for evaluating a truck ban scheme from the environmental improvement aspect on a realistic logistics...

City logistics aims globally to optimize logistics systems within an urban area by considering the costs and benefits of schemes to the public and private sectors alike. Private shippers and freight operators aim to reduce their freight costs, while the community attempts to alleviate traffic...