Epidemiologic methods were developed to prove general causation: identifying exposures that increase the risk of particular diseases. Courts often are more interested in specific causation: On balance of probabilities, was the plaintiff's disease caused by exposure to the agent in question? Some...

Selected Conference Proceedings

Many studies draw inferences about multiple endpoints but ignore the statistical implications of multiplicity. Effects inferred to be positive when there is no adjustment for multiplicity can lose their statistical significance when multiplicity is taken into account, perhaps explaining why such...

Consider the problem of constructing a fixed-length confidence interval for [theta]0 from the observation Y ~ N([theta]0, [sigma]2), when we know a priori that [theta]0 [epsilon][-[tau], [tau]]. The length of the minimax confidence interval centered at an affine functional of Y can be computed...