In this paper we propose a simulation study in order to discuss four statistical models dealing with the problem of parameter estimation in enzyme-kinetics. The pseudo-maximumlikelihood estimators for the transform-both-sides-model and the weighted TBS-model are compared with...

The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete...