Patients suffering from a chronic condition often require periodic treatment. For example, patients with End-Stage Renal Disease (ESRD) require dialysis three times a week. These patients are also frequently hospitalized for complications from their treatment, resulting in idle capacity at the...

We incorporate a previously validated mathematical model of a vascularized tumor into an optimal control problem to determine the temporal scheduling of radiotherapy and angiogenic inhibitors that maximizes the control of a primary tumor. Our results reveal that optimal antiangiogenic...